Nicotinamide Mononucleotide (NMN)

Studies suggest that NMN can:

 

Increase Lifespan

Improve Energy

Repair Broken DNA

Improve Blood Flow

Increase Endurance

NMN is derived from Vitamin B3, and is 100% natural, non-GMO, vegan, and gluten-free.

 

Resveratrol

Studies suggest that resveratrol can:

 

Increase Lifespan

Reduce Inflammation

Support Cognitive Function

Antioxidant Protection

Resveratrol is a naturally occurring antioxidant found in grapes, nuts, and wine.  It is 100% natural, non-GMO, vegan, and gluten-free.

 

The Science

Sirtuin genes slow the aging process.

Sirtuins are a group of seven genes that play a critical role in slowing the effects of aging.  As we age, our DNA is damaged, resulting in diminishing health and an overall decline in function.  The sirtuin genes (SIRT1-7) create proteins that repair damaged DNA and regulate cell health, which can slow the aging process.  For this reason, scientists have nicknamed sirtuins “the longevity genes” and the “guardians of the genome.”

NAD+ is the fuel that powers sirtuins.

Although sirtuins can do amazing things, there’s a problem: sirtuins need a molecule called NAD+ to function.  Without NAD+, sirtuins simply don’t work.  NAD+ is a naturally occurring molecule that can be found in every cell in our bodies.  If sirtuins were a car, NAD+ would be the fuel on which sirtuins run.  When sirtuins run out of fuel, they can no longer regulate our cell health.

As we age, our bodies lose the ability to manufacture NAD+.

Unfortunately, as we age, our NAD+ levels drop significantly.  By the time you turn 50, your NAD+ levels drop to less than half of what they were when you were 20.  Scientists have found that there is a clear link between this drop in NAD+ levels and the effects of aging, likely because sirtuins simply do not have enough fuel to repair our cells.

At this point, you might be wondering, if NAD+ is so important why not just take NAD+?  Researchers tried this and found that, ironically, taking NAD+ does not raise levels of NAD+ within our cells.  All cells have a membrane that separates the interior of a cell from the exterior.  It appears NAD+ cannot cross through that membrane.  This is a problem because NAD+ can only be utilized by our bodies from within cells.  If NAD+ cannot pass through the cell membrane into our cells, it can’t fuel sirtuin genes.

NMN and resveratrol stimulate the production of NAD+ in as little as 10 minutes after consumption.

Following this discovery, researchers were left with a puzzle: how do we find a molecule that can cross into cells and stimulate NAD+ production?  That’s where NMN and resveratrol come in.  NMN and resveratrol are molecules that can cross our cell membranes, and help the body produce more NAD+ and stimulate the sirtuin genes.  In fact, enzymes within our cells readily convert NMN into NAD+.  As a result, NMN has proven to stimulate all seven sirtuin genes, and has been linked to the repair of damaged DNA.  Resveratrol, on the other hand, stimulates a specific sirtuin gene (SIRT1), and speeds up the rate at which the sirtuin genes work.  As Harvard geneticist David Sinclair, Ph.D. puts it, “You can think of resveratrol as the accelerator pedal for the sirtuin genes and the NMN as the fuel.”

NMN and resveratrol are naturally occurring molecules found in common foods.

But what exactly are these miracle molecules?  NMN and resveratrol are both naturally occurring molecules that are a normal part of our diets.  Resveratrol is an antioxidant found in nuts, grapes, and wine.  NMN is a derivative of Vitamin B3, and can be found in foods such as broccoli, cabbage, cucumbers, edamame, and avocado.  However, these molecules are only present in small amounts in most foods.  That is why some researchers believe it is important to take NMN and resveratrol supplements to combat the effects of aging.

Harvard geneticist and anti-aging expert takes 1 gram of NMN and 0.5 grams of resveratrol every morning.

So how can you put this research to work to slow down the aging process?  We can turn once again to Dr. Sinclair, a leading pioneer in the science of anti-aging, for guidance.  Dr. Sinclair’s routine involves taking 1 gram of NMN and 0.5 grams of resveratrol every morning.  Both are powders that can be mixed in with water and most types of food or drink.  This method of supplementation has been shown to raise cellular NAD+ levels significantly within an hour of consumption.

New research debunks a common NMN myth.

There is a myth circulating around the internet that NMN, like NAD+, cannot be absorbed into the cell, and, therefore, cannot stimulate NAD+ production.  This myth has been thoroughly debunked by recent ground-breaking research.  An international research team discovered that a specific gene, named Slc12a8, codes for a molecule that transports NMN directly into the cell.  These researchers found that NMN is readily absorbed into cells and stimulates the production of NAD+ in as little as 10 to 30 minutes after consumption.  This study also discovered that NMN performs better than other NAD+ precursors, such as NR.

Resources:

NMN Direct

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Resveratrol with Piperine

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